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Translational Bioinformatics Mini-Symposium

Translational Bioinformatics Mini-Symposium Spotlights Collaborative Opportunities

More than 100 people attended this inaugural event, which showcased informatics projects in immunology, omics, and complex diseases like cancer. The theme, “Forging New Bioinformatics Collaborations,” helped start a dialogue between bioinformatics and several other affiliated disciplines (biostatistics, structural analytics, network medicine).

Dr. James J. Cimino, director of the Informatics Institute and co-director of the CCTS, opened the symposium with a quick review of the differences in bioinformatics, clinical research informatics, and clinical informatics at UAB. “Bioinformatics is a very strong tradition here, providing support for over a decade to researchers who need help analyzing their biological data.” He explained that CCTS informatics also connects investigators to biomedical and clinical informatics expertise (see the CCTS Informatics Gateway to learn more and submit a request for project assistance). 

At the same time, the Informatics Institute is bringing in new faculty whose research will be oriented to the "scholarship of facilitation," going beyond support to explore new theories anad methods that will apply to a broad spectrum of biomedical research problems. “Personalized medicine is where this is all going to come together,” he said, “to improve care of patients from the molecular level all the way up to the population level.”

Dr. Jake Y. Chen, Informatics Institute associate director and chief bioinformatics officer at UAB, highlighted some of the challenges in reaching the promise of personalized medicine in his talk. “Omics data are less than useful unless data are curated, linked, and aggregated with contextual knowledge.” The goal, he said, is to construct computerized models of complex biosystems that are understandable. To get there, future bioinformaticians will need skills not only in engineering/programming, but also data wrangling and processing, disease biology for perspective, and “a little bit of data artistry,” or the ability to help data tell their story. “Omics and computing have the potential to turn medicine into a practice of data science for human well-beings.” He reviewed the pros and cons of different approaches to gene modeling for drug discovery, ending with a new, five-step process for generating a gene terrain map, which “enables discovery of gene set modules based on topology and expression together.”  

The half-day event was cohosted by CCTS, the UAB Informatics Institute, the UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC), the UAB Division of Clinical Immunology and Rheumatology, and the Multidisciplinary Clinical Research Center. The complete list of topics and speakers is below.

Intro

James J. Cimino, MD, director, Informatics Institute and CCTS co-director

Session 1

“Informatics for Immunology” B-Cell Repertoire Sequencing, Multi-parameter Flow Cytometry, and Data Visualization” 
Alex Rosenberg, PhD, associate professor, Microbiology, Informatics Institute adjunct

Structural Variation Analysis from Short and Long Reads” 
Zechen Chong, PhD, assistant professor, Genetics, Informatics Institute adjunct 

“Single Cell Genomics and Data Analysis”
Min Gao, PhD, bioinformatics scientist, Informatics Institute adjunct

“Transforming Omics Data and Visual Storytelling”
Jake Chen, PhD, professor, Genetics, chief bioinformatics officer, and associate director, Informatics Institute

Panel Discussion—“How to Engage Bioinformaticians for Omics Analysis?”
David Crossman, PhD, assistant professor, Genetics, and Bioinformatics director, Heflin Center for Genomic Science Core Laboratories (moderator)

Session 2

“Bioinformatics and Biostatistics—Overlaps and Distinctions”
Xiangqin Cui, PhD, associate professor of Biostatistics

“Network Medicine Approaches to Complex Diseases”
Merry-Lynn McDonald, PhD, assistant professor, Medicine

“A Novel Gene-Expression Signature for Ovarian Cancer Prognosis”
Malay Basu, PhD, assistant professor, Pathology, Informatics Institute adjunct

“Challenges in the Bioinformatics of Metabolomics”
Stephen Barnes, PhD, professor, Pharmacology and Toxicology

Panel Discussion—“How to Be

"How to Benefit from Bioinformatics for Translational Biomedical Research”
Elliot Lefkowitz, PhD, professor, Microbiology, director, CCTS Informatics Services, Informatics Institute adjunct (moderator)

Closing

S. Louis Bridges, Jr. MD, PhD, professor, Medicine, director, CAMBAC

 A video of several presentations is available on the CCTS YouTube channel.

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